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Graduate School of Medicine教員紹介：古川 聡
| 氏名 |
古川 聡
フルカワ サトシ FURUKAWA, Satoshi |
|---|---|
| 職位 | 教授（特任） |
| 所属教室 |
生命科学研究センター |
| 専門分野 | 宇宙医学 |
| 研究テーマ | 宇宙医学 |
| 略歴 | 1989年 東京大学医学部医学科卒業、旧第1外科にて消化器外科の臨床・研究に従事 1999年 宇宙開発事業団(現 宇宙航空研究開発機構(JAXA))入社 2011年 国際宇宙ステーション（ISS）に約5ヶ月半滞在。「きぼう」日本実験棟での実験やISSの維持管理を行ったほか、最後のスペースシャトルミッションとなったSTS-135の支援などを実施 2023-2024年 クルードラゴン宇宙船運用７号機(Crew-７)Endurance号に搭乗し、第69次/第70次長期滞在クルーとしてISSに約6ヶ月半滞在。地上では得られない宇宙での微小重力環境を使い地上の生活を良くする様々な実験や、有人月探査やその先に向けた技術実証等を遂行 2026年 JAXA宇宙飛行士を卒業(退職)して杏林大学特任教授となる |
| 所有する学位 | 博士（医学） |
| 論文・著書等を含む主要研究業績 |
Furukawa S, Chatani M, Higashitani A, Higashibata A, Kawano F, Nikawa T, Numaga-Tomita T, Ogura T, Sato F, Sehara-Fujisawa A, Shinohara M, Shimazu T, Takahashi S, Watanabe-Takano H: Findings from recent studies by the Japan Aerospace Exploration Agency examining musculoskeletal atrophy in space and on Earth. npj Microgravity 7(1):18, 2021. doi: 10.1038/s41526-021-00145-9 Furukawa S, Nagamatsu A, Nenoi M, Fujimori A, Kakinuma S, Katsube T, Wang B, Tsuruoka C, Shirai T, Nakamura AJ, Sakaue-Sawano A, Miyawaki A, Harada H, Kobayashi M, Kobayashi J, Kunieda T, Funayama T, Suzuki M, Miyamoto T, Hidema J, Yoshida Y, and Takahashi A: Space Radiation Biology for “Living in Space”. Biomed Res Int 2020: 4703286, 2020. doi: 10.1155/2020/4703286. Akiyama T, Horie K, Hinoi E, Hiraiwa M, Kato A, Maekawa Y, Takahashi A, Furukawa S: How Does Spaceflight Affect the Acquired Immune System? npj Microgravity 6:14, 2020. doi: 10.1038/s41526-020-0104-1. Husna N, Aiba T, Fujita SI, Saito Y, Shiba D, Kudo T, Takahashi S, Furukawa S, Muratani M: Release of CD36-associated cell-free mitochondrial DNA and RNA as a hallmark of space environment response. Nat Commun 15(1):4814, 2024. doi: 10.1038/s41467-023-41995-z. Otsuka K, Cornelissen G, Furukawa S, Shibata K, Kubo Y, Mizuno K, Aiba T, Ohshima H, Mukai C: Unconscious mind activates central cardiovascular network and promotes adaptation to microgravity possibly anti-aging during 1-year-long spaceflight. Sci Rep 12(1):11862, 2022. doi: 10.1038/s41598-022-14858-8. Hagio S, Ishihara A, Terada M, Tanabe H, Kibushi B, Higashibata A, Yamada S, Furukawa S, Mukai C, Ishioka N, Kouzaki M: Muscle synergies of multidirectional postural control in astronauts on Earth after a long-term stay in space. J Neurophysiol 127(5):1230-1239, 2022. doi: 10.1152/jn.00232.2021. Ohira T, Ino Y, Kimura Y, Nakai Y, Kimura A, Kurata Y, Kagawa H, Kimura M, Egashira K, Matsuda C, Ohira Y, Furukawa S, Hirano H: Effects of microgravity exposure and fructo-oligosaccharide ingestion on the proteome of soleus and extensor digitorum longus muscles in developing mice. npj Microgravity 7(1):34, 2021. doi: 10.1038/s41526-021-00164-6 Otsuka K, Cornelissen G, Furukawa S, Kubo Y, Shibata K, Mizuno K, Ohshima H, Mukai C: Astronauts well-being and possibly anti-aging improved during long-duration spaceflight. Sci Rep 11(1): 14907, 2021. doi: 10.1038/s41598-021-94478-w Iwasaki KI, Ogawa Y, Kurazumi T, Imaduddin SM, Mukai C, Furukawa S, Yanagida R, Kato T, Konishi T, Shinojima A, Levine BD, Heldt T: Long-duration spaceflight alters estimated intracranial pressure and cerebral blood velocity. J Physiol 599(4):1067-1081, 2021. doi: 10.1113/JP280318. Satoh K, Yamazaki T, Furukawa S, Mukai C, Makimura K: Identification of fungi isolated from astronaut nasal and pharyngeal smears and saliva. Microbiol Immunol 65(2):89-94, 2021. doi: 10.1111/1348-0421.12872. Sugita T, Yamazaki T, Cho O, Furukawa S, Mukai C: The skin mycobiome of an astronaut during a 1-year stay on the International Space Station. Med Mycol 59(1):106-109, 2021. doi: 10.1093/mmy/myaa067. Ishihara A, Terada M, Hagio S, Higashibata A, Yamada S, Furukawa S, Mukai C, Ishioka N: Blood flow in astronauts on Earth after long space stay. Acta Astronautica 175:462-464 2020. doi: 10.1016/j.actaastro.2020.05.017. Abe T, Mishima K, Kitamura S, Hida A, Inoue Y, Mizuno K, Kaida K, Nakazaki K, Motomura Y, Maruo K, Ohta T, Furukawa S, Dinges DF, Ogata K: Tracking intermediate performance of vigilant attention using multiple eye metrics. Sleep 43(3): zsz219, 2020. doi: 10.1093/sleep/zsz219. Sasahara S, Andrea CS, Suzuki G, Oi Y, Doki S, Hori D, Ohira T, Matsuda C, Inoue N, Takahashi T, Ohtaki Y, Saito T, Furukawa S, Ogata K, Matsuzaki I: Effect of exercise on brain function as assessed by functional near-infrared spectroscopy during a verbal fluency test in a simulated international space station environment: A single-case, experimental ABA study in Japan. Acta Astronautica 166:238−242, 2020. doi: 10.1016/j.actaastro.2019.10.013. Matsuda C, Kato T, Inoue-Suzuki S, Kikuchi J, Ohta T, Kagawa M, Hattori M, Kobayashi H, Shiba D, Shirakawa M, Mizuno H, Furukawa S, Mukai C, Ohno H: Dietary intervention of mice using an improved Multiple Artificial-gravity Research System (MARS) under artificial 1 g. npj Microgravity 5:16, 2019. doi: 10.1038/s41526-019-0077-0. Otsuka K, Cornelissen G, Kubo Y, Shibata K, Mizuno K, Ohshima H, Furukawa S, Mukai C: Anti-aging effects of long-term space missions, estimated by heart rate variability. Sci Rep 9(1):8995, 2019. doi: 10.1038/s41598-019-45387-6. Kato T, Yanagida R, Takko C, Kurazumi T, Inoue N, Suzuki G, Ogawa Y, Furukawa S, Iwasaki KI: Dynamic cerebral autoregulation after confinement in an isolated environment for 14 days. Environ Health Prev Med 23(1):61, 2018. doi: 10.1186/s12199-018-0751-y. Sakai T, Moteki Y, Takahashi T, Shida K, Kiwaki M, Shimakawa Y, Matsui A, Chonan O, Morikawa K, Ohta T, Ohshima H, Furukawa S: Probiotics into outer space: feasibility assessments of encapsulated freeze-dried probiotics during 1 month's storage on the International Space Station. Sci Rep 8(1):10687, 2018. doi: 10.1038/s41598-018-29094-2. Otsuka K, Cornelissen G, Kubo Y, Shibata K, Hayashi M, Mizuno K, Ohshima H, Furukawa S, Mukai C: Circadian challenge of astronauts’ unconscious mind adapting to microgravity in space, estimated by heart rate variability. Sci Rep 8(1):10381, 2018. doi: 10.1038/s41598-018-28740-z. Egawa M, Haze S, Gozu Y, Hosoi J, Onodera T, Tojo Y, Katsuyama M, Hara Y, Katagiri C, Inoue N, Furukawa S, Suzuki G: Evaluation of psychological stress in confined environments using salivary, skin, and facial image parameters. Sci Rep 8(1):8264, 2018. doi: 10.1038/s41598-018-26654-4. Ohira T, Higashibata A, Seki M, Kurata Y, Kimura Y, Hirano H, Kusakari Y, Minamisawa S, Kudo T, Takahashi S, Ohira Y, Furukawa S: The effects of heat stress on morphological properties and intracellular signaling of denervated and intact soleus muscles in rats. Physiol Rep 5(15): e13350, 2017. doi: 10.14814/phy2.13350. Otsuka K, Cornelissen G, Furukawa S, Kubo Y, Hayashi M, Shibata K, Mizuno K, Aiba T, Ohshima H, Mukai C: Long-term exposure to space's microgravity alters the time structure of heart rate variability of astronauts. Heliyon 2(12):e00211, 2016. doi: 10.1016/j.heliyon.2016.e00211. Otsuka K, Cornelissen G, Kubo Y, Hayashi M, Yamamoto N, Shibata K, Aiba T, Furukawa S, Ohshima H, Mukai C: Intrinsic cardiovascular autonomic regulatory system of astronauts exposed long-term to microgravity in space: observational study. npj Microgravity.1:15018, 2015. doi: 10.1038/npjmgrav.2015.18. Matsuda T, Saito H, Fukatsu K, Han I, Inoue T, Furukawa S, Ikeda S, Hidemura A, Kang W: Differences in neutrophil death among beta-lactam antibiotics after in vitro killing of bacteria. Shock 18(1):69-74, 2002. doi: 10.1097/00024382-200207000-00013. Lin MT, Saito H, Furukawa S, Fukushima R, Fukatsu K, Lee PH, Chang KJ, Chen WJ: Alanyl-glutamine enriched total parenteral nutrition improves local, systemic, and remote organ responses to intraperitoneal bacterial challenge. JPEN J Parenter Enteral Nutr 25(6):346-51, 2001. doi: 10.1177/0148607101025006346. Han I, Saito H, Fukatsu K, Inoue T, Yasuhara H, Furukawa S, Matsuda T, Lin MT, Ikeda S: Ex vivo fluorescence microscopy provides simple and accurate assessment of neutrophil-endothelial adhesion in the rat lung. Shock 16(2):143-7, 2001. doi: 10.1097/00024382-200116020-00010. Ikeda S, Saito H, Fukatsu K, Inoue T, Han I, Furukawa S, Matsuda T, Hidemura A: Dietary restriction impairs neutrophil exudation by reducing CD11b/CD18 expression and chemokine production. Arch Surg 136(3):297-304, 2001. doi: 10.1001/archsurg.136.3.297. Matsuda T, Saito H, Fukatsu K, Han I, Inoue T, Furukawa S, Ikeda S, Hidemura A: Cytokine-modulated inhibition of neutrophil apoptosis at local site augments exudative neutrophil functions and reflects inflammatory response after surgery. Surgery 129(1):76-85, 2001. doi: 10.1067/msy.2001.109060. Ikeda S, Saito H, Inoue T, Fukatsu K, Han I, Furukawa S, Matsuda T, Hidemura A: Malnutrition impairs CD11b/CD18 expression on circulating polymorphonuclear neutrophils and subsequent exudation into inflammatory sites in the early phase of glycogen-induced murine peritonitis. JPEN J Parenter Enteral Nutr 24(5):276-9, 2000. doi: 10.1177/0148607100024005276. Furukawa S, Saito H, Inoue T, Matsuda T, Fukatsu K, Han I, Ikeda S, Hidemura A: Supplemental glutamine augments phagocytosis and reactive oxygen intermediate production by neutrophils and monocytes from postoperative patients in vitro. Nutrition 16(5):323-9, 2000. doi: 10.1016/s0899-9007(00)00228-8. Furukawa S, Saito H, Matsuda T, Inoue T, Fukatsu K, Han I, Ikeda S, Hidemura A, Muto T: Relative effects of glucose and glutamine on reactive oxygen intermediate production by neutrophils. Shock 13(4):274-8, 2000. doi: 10.1097/00024382-200004000-00004. Matsuda T, Saito H, Inoue T, Fukatsu K, Lin MT, Han I, Furukawa S, Ikeda S, Muto T: Ratio of bacteria to polymorphonuclear neutrophils (PMNs) determines PMN fate. Shock 12(5):365-72, 1999. Saito H, Furukawa S, Matsuda T: Glutamine as an immunoenhancing nutrient. JPEN J Parenter Enteral Nutr 23(5 Suppl): S59-61, 1999. Inaba T, Saito H, Inoue T, Han I, Furukawa S, Matsuda T, Ikeda S, Muto T: Growth hormone/insulin-like growth factor 1 axis alterations contribute to disturbed protein metabolism in cirrhosis patients after hepatectomy. J Hepatol 31(2):271-6, 1999. doi: 10.1016/s0168-8278(99)80224-4. Fukushima R, Saito H, Inoue T, Fukatsu K, Inaba T, Han I, Furukawa S, Lin MT, Muto T: Prophylactic treatment with growth hormone and insulin-like growth factor I improve systemic bacterial clearance and survival in a murine model of burn-induced gut-derived sepsis. Burns 25(5):425-30, 1999. doi: 10.1016/s0305-4179(98)00188-0. Furukawa S, Saito H, Lin MT, Futakawa N, Yasuhara H, Kimura W, Inagawa H, Ono K, Maekawa K, Muto T: Enteral administration of glutamine in purulent peritonitis. Nutrition 15(1):29-31, 1999. doi: 10.1016/s0899-9007(98)00110-5. Fukatsu K, Saito H, Han I, Inoue T, Furukawa S, Matsuda T, Ikeda S, Yasuhara H, Muto T: Concomitant increase in neutrophil adhesion to inflammatory peritoneum and remote organs during peritonitis. J Surg Res 81(2):156-63, 1999. doi: 10.1006/jsre.1998.5454. Matsuda T, Saito H, Inoue T, Fukatsu K, Han I, Furukawa S, Ikeda S, Muto T: Growth hormone inhibits apoptosis and up-regulates reactive oxygen intermediates production by human polymorphonuclear neutrophils. JPEN J Parenter Enteral Nutr 22(6):368-74, 1998. doi: 10.1177/0148607198022006368. Inoue T, Saito H, Matsuda T, Fukatsu K, Han I, Furukawa S, Ikeda S, Muto T: Growth hormone and insulin-like growth factor I augment bactericidal capacity of human polymorphonuclear neutrophils. Shock 10(4):278-84, 1998. doi: 10.1097/00024382-199810000-00008. Fukatsu K, Saito H, Han I, Furukawa S, Lin MT, Matsuda T, Ikeda S, Inoue T, Yasuhara H, Muto T: Nitric oxide donor decreases neutrophil adhesion in both lung and peritoneum during peritonitis. J Surg Res 74(2):119-24, 1998. doi: 10.1006/jsre.1997.5234. Inoue T, Saito H, Tsuno N, Fukatsu K, Lin MT, Inaba T, Han I, Furukawa S, Ikeda S, Matsuda T, Muto T: Effects of growth hormone and insulin-like growth factor I on opsonin receptor expression on local and systemic phagocytes in a lethal peritonitis model. Crit Care Med 26(2):338-43, 1998. doi: 10.1097/00003246-199802000-00038. Fukatsu K, Saito H, Matsuda T, Ikeda S, Furukawa S, Muto T: Influences of type and duration of antimicrobial prophylaxis on an outbreak of methicillin-resistant Staphylococcus aureus and on the incidence of wound infection. Arch Surg 132(12):1320-5, 1997. doi: 10.1001/archsurg.1997.01430360066012. Furukawa S, Saito H, Fukatsu K, Hashiguchi Y, Inaba T, Lin MT, Inoue T, Han I, Matsuda T, Muto T: Glutamine-enhanced bacterial killing by neutrophils from postoperative patients. Nutrition 13(10):863-9, 1997. doi: 10.1016/s0899-9007(97)00271-2. Furukawa S, Saito H, Inaba T, Lin MT, Inoue T, Naka S, Fukatsu K, Hashiguchi Y, Han I, Matsuda T, Ikeda S, Muto T: Glutamine-enriched enteral diet enhances bacterial clearance in protected bacterial peritonitis, regardless of glutamine form. JPEN J Parenter Enteral Nutr 21(4):208-14, 1997. doi: 10.1177/0148607197021004208. Fukatsu K, Saito H, Han I, Furukawa S, Hashiguchi Y, Lin MT, Matsuda T, Inaba T, Inoue T, Ikeda S, Yasuhara H, Muto T: Nitric oxide inhibition decreases neutrophil adhesion at the inflammatory site, while increasing adhesion in remote organs in peritonitis. J Surg Res 68(1):79-86, 1997. doi: 10.1006/jsre.1997.5018. Naka S, Saito H, Hashiguchi Y, Lin MT, Furukawa S, Inaba T, Fukushima R, Wada N, Muto T: Alanylglutamine-enriched total parenteral nutrition improves protein metabolism more than branched chain amino acid-enriched total parenteral nutrition in protracted peritonitis. J Trauma 42(2):183-90, 1997. doi: 10.1097/00005373-199702000-00003. Lin MT, Saito H, Fukushima R, Inaba T, Fukatsu K, Inoue T, Furukawa S, Han I, Matsuda T, Muto T: Preoperative total parenteral nutrition influences postoperative systemic cytokine responses after colorectal surgery. Nutrition 13(1):8-12, 1997. doi: 10.1016/s0899-9007(97)90871-6. Naka S, Saito H, Hashiguchi Y, Lin MT, Furukawa S, Inaba T, Fukushima R, Wada N, Muto T: Alanyl-glutamine-supplemented total parenteral nutrition improves survival and protein metabolism in rat protracted bacterial peritonitis model. JPEN J Parenter Enteral Nutr 20(6):417-23, 1996. doi: 10.1177/0148607196020006417. Inoue T, Saito H, Hashiguchi Y, Fukatsu K, Inaba T, Lin MT, Han I, Furukawa S, Muto T: Growth hormone and insulin-like growth factor I augment Escherichia coli-killing activity of murine peritoneal exudative cells. Shock 6(5):345-50, 1996. doi: 10.1097/00024382-199611000-00008. Fukatsu K, Saito H, Han I, Yasuhara H, Lin MT, Inoue T, Furukawa S, Inaba T, Hashiguchi Y, Matsuda T, Muto T: The greater omentum is the primary site of neutrophil exudation in peritonitis. J Am Coll Surg 183(5):450-6, 1996. Fukatsu K, Saito H, Fukushima R, Lin MT, Inoue T, Inaba T, Furukawa S, Han I, Muto T: Effects of three inhibitors of nitric oxide synthase on host resistance to bacterial infection. Inflamm Res 45(3):109-12, 1996. doi: 10.1007/BF02265161. Lin MT, Saito H, Fukushima R, Inaba T, Fukatsu K, Inoue T, Furukawa S, Han I, Muto T: Route of nutritional supply influences local, systemic, and remote organ responses to intraperitoneal bacterial challenge. Ann Surg 223(1):84-93, 1996. doi: 10.1097/00000658-199601000-00012. |
| 所属学会 |
日本宇宙航空環境医学会 日本宇宙生物科学会 |